Multiple sclerosis - All you really need to know

Consider the diagnosis if any of the following:

It probably isn't MS if:

Acute admission is required if new onset:

otherwise MRI and neurology referral can be done non-urgently

* the classic pathognomonic lesion is optic neuritis on fundoscopy and unilateral internuclear opthalmoplegia (INO)

INO is disruption of the medial longitudinal fasciculus of the brainstem that interconnects CN III, IV, VI governing eye movement. One eye doesn't turn in when looking to the side and the other one develops nystagmus.