Diabetic Ketoacidosis

Key point: Insulin deficiency +/- excess glucagon


Net effects ('starvation in a land of plenty')



Compensatory mechanisms

Serum potassium and DKA

Therefore can be elevated, normal or depressed (but usually total body levels are depleted)

Treatment principles

Complications of treatment

malonyl CoA: required for FFA elongation
CPT-1: assists in movement of acyl CoA into mitochondria
Acyl CoA: FFA + CoA. Beta-oxidised to Acetyl CoA.
Ketone bodies: formed from condensation of two acetyl CoA into acetoacetate