Advanced pharmacology concepts

PHARMACODYNAMICS (how a drug exerts it effect on the body)


Therapeutic (Effective), Toxic, Lethal dose


Drugs can block an effect by:

Other pharmacodynamic concepts

Down-regulation (and tolerance)
Up-regulation (and rebound effect)

PHARMACODYNAMICS (what happens to the drug after it is administered)

Other important concepts

First pass metabolism
Enzyme induction
Enzyme inhibition
Phase I reaction
Phase II reaction
1st order kinetics (typical)
Zero order kinetics (sometimes)
The observation that drug levels fall at a constant rate regardless of its current concentration
Multi-compartmental model
Drug barriers
Some important terms

Drug interactions - a summary

Dosing schedules are based on combination of

Maintenance dose

Loading dose