Blood component therapy - Heriditary conditions

See Assessing severity of Bleeding

Haemophilia A,B; VWF Deficiency

Component specific therapy (preferred)

Mild Moderate Severe
Haemophilia A DDAVP 0.3mcg/kg (30min)
+/-
Factor VIII 15-25 IU/kg		 Factor VIII 20-25 IU/kg Factor VIII 50 IU/kg 12/24
Haemophilia B Factor IX 15-25 IU/kg Factor IX 20-25 IU/kg Factor IX 20-25 IU/kg
VWF Deficiency DDAVP
+/-
Factor VIII		 Factor VIII Factor VIII

Non-specific therapy (if component unavailable)

Mild Moderate Severe
Haemophilia A DDAVP 0.3mcg/kg (30min)
+/-Cryoprecipitate 2.5 ml/kg 		Cryoprecipitate 5 ml/kg Cryoprecipitate 10 ml/kg
Haemophilia B FFP FFP FFP
VWF Deficiency DDAVP
+/-Cryoprecipitate		 Cryoprecipitate Cryoprecipitate