Clotting pharmacology

Antiplatelets

• Aspirin - inhibit COX 1 conversion of arachnidonic acid to TXA2
• Clopidogrel, Ticlopidine - ADP inhibitor
• GIIb/IIIa inhibitors
• Dipyridamole - adenosine reuptake inhibitor

Anticoagulants

• Warfarin (inhibits Vitamin K) - II, VII, IX, X ('TV channel factors')
• Heparin (Activates antithrombin III > Factor II, IX, X*, XI, XII inhibition)
• Direct thrombin inhibitors

Thrombolytics

• e.g. Streptokinase, tissue plasminogen activator, tenectaplase - inhibit plasminogen conversiion to plasmin

Maintains clotting function

• Vitamin K
• Calcium

Haemostatics

• DDAVP/Desmopressin (^ VWF release > ^ Factor VIII)
• Tranexamic acid (inhibits plasminogen converstion to plasmin)
• Aminocaproic acid (inhibits plasmin)

Clotting factors

• Fresh frozen plasma - Factor VIII / XII, fibrinogen (II)
• Cryopreciptate - Factor VII
• Factor VIII, IX
• Activated Factor VII
• Prothrombinex (Factor II)
  + other rarely prescribed factors (for specific congenital deficiecies)