OPIATES

Drug Onset (min) Peak
(h)
Duration
(h)
Average Dosing Interval
(h)

Equianalgesic Doses* (mg)

PO IM IV

I.M.

Oral

Alfentanil     0 ? ? - ? NA
Codeine 30-60 10-30   0.5-1 4-6 3 120 200
Fentanyl   7-15 0 ND 1-2 1 0.1 NA
Hydromorphone 15-30     0.5-1 4-6 4 1.5 7.5
Pethidine 10-15 10-15 5 0.5-1 2-4 3 75 300
Methadone 30-60   10-20 0.5-1 4-6 (acute)
>8 (chronic)
8 10 (acute)
2-4 (chronic)
20 (acute)
2-4 (chronic)
Morphine 15-60   5 0.5-1 (PO/IM/SC)
0.3 (IV)
3-6 4 10 60 (acute)
30 (chronic)
Oxycodone 10-15     0.5-1 4-6 4 NA 20
Propoxyphene 30-60     2-2.5 4-6 6 ? 130-200
Sufentanil     1.3-3 ? ? ? 0.02 NA