Ischaemic Stroke
TweetIntroduction: High 12 months mortality e.g. 25%. Prognosis depends on cause, extent and location of stroke. Prevention is better than cure! Definition: Stroke secondary to ischaemia Pathology Usually use… Read more »
Category: Uncategorized
Stroke – Pathology
TweetDefinition: Acute cerebrovascular event resulting in a permanent neurological deficit (cf Transient Ischaemic Attack) Pathology Typically due to underying Vascular Disease but there are other rarer causes such as Vasculitis… Read more »
Vascular Disease – Acute Complications
TweetIntroduction – Major cause of acute presentations to hospital. Clinicians should be wary this as a cause in any patient with potential Vascular Risk Factors and presenting with acute pain… Read more »
Vascular Disease – Risk Factors
Tweet Diabetes mellitus Smoking Chronic hypertension Hyperlipidaemia Age
Vascular Disease – Chronic Complications
Tweet Brain – Vascular dementia Heart – Ischaemic cardiomyopathy > Chronic Heart Failure Extremities – Peripheral vascular disease (claudication) Kidneys – Chronic renal failure
Vascular disease – Pathology
TweetEpidemiology: Major disease burden in the world. Cardiovascular and cerebrovascular disease Cause: see Vascular risk factors Pathology: Chronic narrowing of arteries due to atherosclerosis resulting in gradually impaired function to supplied… Read more »
Diabetes Mellitus – Therapeutics
TweetOptions Stimulate insulin release (sulphonylureas) e.g. glicazide Improve tissue utilisation of glucose (biguanides) e.g. metformin increase renal excretion of glucose (SGLT2 inhibtors) e.g. dapaglifozin alter GIT absorption of CHO (Alpha-glucosidase… Read more »
Diabetes Mellitus (‘Diabetes’)
TweetDefinition – persistently elevated blood glucose due to either insulin deficiency and/or insulin resistance Epidemiology – major public health issue and disease burden resulting in vascular disease Diagnostic criteria –… Read more »